[Connective matrix and localization of a biological signal: demonstration of a matrix receptor for interferon-gamma in basement membranes]
| Autor: | Lortat-Jacob, H., Kleinman, H., Grimaud, J. A. |
|---|---|
| Přispěvatelé: | Institut Pasteur de Lyon, Réseau International des Instituts Pasteur (RIIP), Lortat-Jacob, Hugues |
| Jazyk: | francouzština |
| Rok vydání: | 1990 |
| Předmět: |
MESH: Chondroitin Sulfate Proteoglycans
MESH: Connective Tissue MESH: Humans Binding Sites MESH: Interferon-gamma MESH: Extracellular Matrix Basement Membrane Extracellular Matrix Interferon-gamma MESH: Binding Sites Chondroitin Sulfate Proteoglycans MESH: Heparitin Sulfate Connective Tissue [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology MESH: Heparan Sulfate Proteoglycans Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Heparitin Sulfate MESH: Basement Membrane Heparan Sulfate Proteoglycans |
| Zdroj: | Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Elsevier, 1990, 311 (4), pp.143-7 |
| ISSN: | 0764-4469 |
| Popis: | International audience; Extracellular matrix has a variety of biological effects on cells, including increased cell adhesion, migration, division and differentiation. Cells are also regulated by soluble factors such as cytokines. We have investigated the binding of interferon-gamma to basement membrane. Interferon-gamma binds basement membrane with a high affinity (kD = 1.5 x 10(-9) M). The binding site is located on the glycosaminoglycan part of the heparan sulfate proteoglycan. This result suggests that extracellular matrix interacts with interferon-gamma and could modulate the cellular response to such factors. |
| Databáze: | OpenAIRE |
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