Antiphospholipid syndrome and factor V Leiden. Three cases with recurrent venous thrombosis

Autor:	Guis-Sabatier S, jean roudier, Arnoux D, Rochwerger A, Roux H, Jp, Mattei
Předmět:	Adult Male Venous Thrombosis Recurrence Factor V Humans Female Middle Aged Antiphospholipid Syndrome Activated Protein C Resistance
Zdroj:	Europe PubMed Central
Popis:	Recurrent thrombosis is a common complication of various rheumatic disorders and is part of the definition of antiphospholipid syndrome. We report three cases of recurrent venous thrombosis due not only to antiphospholipid syndrome with a normal activated partial thromboplastin time but also to resistance to activated protein C caused by the factor V Leiden mutation. These three cases confirm that thrombotic disease is frequently multifactorial and suggest that resistance to activated protein C should be looked for routinely in patients with suggestive clinical manifestations, particularly when standard clotting tests are normal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5cb3b4c3370726ddf18e688c989b308b http://europepmc.org/abstract/med/10769107 Zobrazit plný text záznamu