Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection
| Autor: | Jabrane-Ferrat, Nabila |
|---|---|
| Přispěvatelé: | Centre de recherche en pharmacologie - santé (CRPS), Centre National de la Recherche Scientifique (CNRS), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), JABRANE-FERRAT, Nabila |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
receptor
Immunology MESH: Pregnancy / immunology Review [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Decidua Animals Humans decidual natural killer MESH: Animals [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology MESH: Humans cytokines congenital infection Killer Cells Natural [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics MESH: Decidua / cytology Virus Diseases [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology embryonic structures MESH: Decidua / immunology [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Killer Cells Natural / immunology Female pregnancy MESH: Female |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Frontiers, 2019, 10, pp.1397. ⟨10.3389/fimmu.2019.01397⟩ Frontiers in Immunology, 2019, 10, pp.1397. ⟨10.3389/fimmu.2019.01397⟩ |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2019.01397⟩ |
| Popis: | International audience; The hallmark of human early pregnancy is the accumulation of a unique population of Natural Killer (dNK) cells at the main maternal-fetal interface, the decidua basalis. dNK cells play a crucial role in successful placentation probably by orchestrating the invasion of trophoblast cells deep into the decidua basalis and remodeling of the maternal spiral arteries. Recent advances in the field emphasize the importance of the local microenvironment in shaping both the phenotype and the effector functions of these innate lymphoid cells. Despite slow progress in the field, ex vivo studies revealed that dNK cells sense and destroy infected cells in order to protect the fetus from invading pathogens. In this review, we will discuss key features of dNK cells during healthy pregnancy as well as their functional adaptations in limiting pathogen dissemination to the growing conceptus. The challenge is to better understand the plasticity of dNK cells in the maternal-fetal interface. Such insights would enable greater understanding of the pathogenesis in congenital infections and pregnancy disorders |
| Databáze: | OpenAIRE |
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