[Homocysteine: relations to ischemic cardiovascular diseases]

Autor: Piolot, A., Nadler, F., Parez, N., Jacotot, B.
Přispěvatelé: Université Pierre et Marie Curie - Paris 6 (UPMC)
Jazyk: francouzština
Rok vydání: 1996
Předmět:
Zdroj: La Revue De Médecine Interne
La Revue De Médecine Interne, Elsevier, 1996, 17 ((1)), pp.34-45
La Revue de Médecine Interne
La Revue de Médecine Interne, 1996, 17 ((1)), pp.34-45
ISSN: 0248-8663
1768-3122
Popis: International audience; Homocysteine, a sulfur-containing amino acid, is an intermediate metabolite of methionine. Patients with homocystinuria and severe hyperhomocysteinemia develop premature arteriosclerosis and arterial thrombotic events, and venous thromboembolism. Studies suggest that moderate hyperhomocysteinemia can be considered as an independent risk factor in the development of premature cardiovascular disease. In vitro, homocysteine has toxic effects on endothelial cells. Homocysteine can promote lipid peroxidation and damage vascular endothelial cells. Moreover, homocysteine interferes with the natural anticoagulant system and the fibrinolytic system. Homocysteinemia should be known in patients with premature vascular diseases, especially in subjects with no risk factors. Folic acid, vitamin B6 can lower homocysteine levels.
Databáze: OpenAIRE
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