| Autor: |
MIEDEMA, F, TERPSTRA, FG, SMIT, JW, VANDERVEEN, JPW, MELIEF, CJM |
| Jazyk: |
angličtina |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Clinical and Experimental Immunology, 61(2), 440-449. Wiley |
| ISSN: |
0009-9104 |
| Popis: |
Immunological studies were performed with the expanded T gamma cells of five patients with T gamma lymphocytosis. All patients showed a stable clinical picture with persistent T gamma lymphocytosis and neutropenia, with or without recurrent infections. The expanded T gamma cells in the blood had the T1-3+4-8+11+M1- phenotype, with the exception of one patient whose cells lacked the T8 marker. The expanded T gamma cell population did not proliferate in response to T cell mitogens and did not show immunoregulatory activity on pokeweed mitogen driven immunoglobulin synthesis. In four of the five patients the T gamma cells had killer cell activity against IgG sensitized mouse mastocytoma cells. Taken together, these results and the data from the literature, it is concluded that T gamma lymphocytosis represents a spectrum of T cell expansions clearly distinct from clinically progressive mature T cell neoplasias. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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