| Autor: |
G, Leone, M D, Volpato, N, Nelli, S, Lamponi, E, Boanini, A, Bigi, A, Magnani |
| Přispěvatelé: |
Leone, G., Volpato, M. D., Nelli, N., Lamponi, S., Boanini, E., Bigi, A., Magnani, A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
Cartilage is a highly organized avascular soft tissue that assembles from nano-to macro-scale to produce a complex structural network. To mimic cartilage tissue, we developed a stable multilayered composite material, characterized by a tailored gradient of mechanical properties. The optimized procedure implies chemical crosslinking of each layer directly onto the previous one and ensures a drastic reduction of the material discontinuities and brittleness. The multilayered composite was characterized by infrared spectroscopy, differential scanning calorimetry, thermogravimetry, and scanning electron microscopy in order to compare its physico-chemical characteristics with those of cartilage tissue. The rheological behavior of the multilayered composite was similar to that of human cartilage. Finally its cytocompatibility toward chondrocytes and osteoblasts was evaluated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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