Embryo-derived and induced pluripotent stem cells: Towards naive pluripotency and chimeric competency in rabbits
| Autor: | Afanassieff, Marielle, Perold, Florence, Bouchereau, Wilhelm, Cadiou, Antoine, Beaujean, Nathalie |
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| Přispěvatelé: | Institut cellule souche et cerveau (U846 Inserm - UCBL1), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), ANR-11-LABX-0042,CORTEX,Construction, Fonction Cognitive et Réhabilitation du Cerveau(2011), ANR-10-IBHU-0003,CESAME,Institut Cerveau et Santé Mentale(2010), Beaujean, Nathalie, Laboratoires d'excellence - Stem Cells in Regenerative Biology and Medicine - - REVIVE2010 - ANR-10-LABX-0073 - LABX - VALID, Construction, Fonction Cognitive et Réhabilitation du Cerveau - - CORTEX2011 - ANR-11-LABX-0042 - LABX - VALID, Instituts Hospitalo-Universitaires B - Institut Cerveau et Santé Mentale - - CESAME2010 - ANR-10-IBHU-0003 - IBHU - VALID |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pluripotency
Chimera [SDV]Life Sciences [q-bio] Induced Pluripotent Stem Cells Chimaera Embryonic Development Gene Expression Regulation Developmental Cell Differentiation [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology Stem cells Rabbit [SDV.BC]Life Sciences [q-bio]/Cellular Biology Embryo Mammalian [SDV] Life Sciences [q-bio] Embryo [SDV.BDD] Life Sciences [q-bio]/Development Biology Animals Rabbits [SDV.BC] Life Sciences [q-bio]/Cellular Biology [SDV.BDD]Life Sciences [q-bio]/Development Biology [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology Embryonic Stem Cells |
| Zdroj: | Experimental Cell Research Experimental Cell Research, Elsevier, 2020, 389 (2), pp.1-8. ⟨10.1016/j.yexcr.2020.111908⟩ |
| ISSN: | 0014-4827 1090-2422 |
| Popis: | International audience; Both embryo-derived (ESC) and induced pluripotent stem cell (iPSC) lines have been established in rabbit. They exhibit the essential characteristics of primed pluripotency. In this review, we described their characteristic features at both molecular and functional levels. We also described the attempts to reprogram rabbit pluripotent stem cells (rbPSCs) toward the naive state of pluripotency using methods established previously to capture this state in rodents and primates. In the last section, we described and discussed our current knowledge of rabbit embryo development pertaining to the mechanisms of early lineage segregation. We argued that the molecular signature of naive-state pluripotency differs between mice and rabbits. We finally discussed some of the key issues to be addressed for capturing the naive state in rbPSCs, including the generation of embryo/PSC chimeras. |
| Databáze: | OpenAIRE |
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