Myocardial Extracellular Volume Estimation by CMR Predicts Functional Recovery Following Acute MI

Autor: Kidambi, A, Motwani, M, Uddin, A, Ripley, DP, McDiarmid, AK, Swoboda, PP, Broadbent, DA, Al Musa, T, Erhayiem, B, Leader, J, Croisille, P, Clarysse, P, Greenwood, JP, Plein, S
Přispěvatelé: Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2015
Předmět:
Male
Time Factors
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
CT and MRI
Myocardial Infarction
acute myocardial infarction
Contrast Media
Magnetic Resonance Imaging
Cine
Ventricular Function
Left
AUC
area under the curve
Percutaneous Coronary Intervention
CMR
cardiac magnetic resonance
contractile function
Predictive Value of Tests
MO
microvascular obstruction
EF
ejection fraction
Humans
cardiovascular diseases
Prospective Studies
Original Research
Aged
LGE
late gadolinium enhancement
Myocardium
LV
left ventricle/ventricular
Reproducibility of Results
ECV
extracellular volume
Recovery of Function
Middle Aged
MOLLI
modified Look-Locker inversion
Myocardial Contraction
AMI
acute myocardial infarction
Treatment Outcome
ROC Curve
Radiology Nuclear Medicine and imaging
Area Under Curve
Multivariate Analysis
cardiovascular system
Linear Models
cardiovascular imaging agents/techniques
ST Elevation Myocardial Infarction
Female
Cardiology and Cardiovascular Medicine
Biomarkers
Zdroj: JACC: Cardiovascular Imaging
JACC: Cardiovascular Imaging, Elsevier/American College of Cardiology, 2017, 10 (9), pp.989--999. ⟨10.1016/j.jcmg.2016.06.015⟩
Jacc. Cardiovascular Imaging
ISSN: 1876-7591
1936-878X
DOI: 10.1016/j.jcmg.2016.06.015⟩
Popis: Objectives In the setting of reperfused acute myocardial infarction (AMI), the authors sought to compare prediction of contractile recovery by infarct extracellular volume (ECV), as measured by T1-mapping cardiac magnetic resonance (CMR), with late gadolinium enhancement (LGE) transmural extent. Background The transmural extent of myocardial infarction as assessed by LGE CMR is a strong predictor of functional recovery, but accuracy of the technique may be reduced in AMI. ECV mapping by CMR can provide a continuous measure associated with the severity of tissue damage within infarcted myocardium. Methods Thirty-nine patients underwent acute (day 2) and convalescent (3 months) CMR scans following AMI. Cine imaging, tissue tagging, T2-weighted imaging, modified Look-Locker inversion T1 mapping natively and 15 min post–gadolinium-contrast administration, and LGE imaging were performed. The ability of acute infarct ECV and acute transmural extent of LGE to predict convalescent wall motion, ejection fraction (EF), and strain were compared per-segment and per-patient. Results Per-segment, acute ECV and LGE transmural extent were associated with convalescent wall motion score (p
Graphical abstract
Databáze: OpenAIRE
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