Effect of tumour necrosis factor-alpha and interleukin-6 promoter polymorphisms on course of Crimean-Congo hemorrhagic fever in Turkish patients
| Autor: | Yilmaz, M., Elaldi, N., Bagci, B., Ismail Sari, Gümüs, E., Yelkovan, I. |
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| Přispěvatelé: | [Yilmaz, Meral] Cumhuriyet Univ, Fac Med, Dept Res Ctr, Sivas, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Fac Med, Dept Nutr & Diet, Sivas, Turkey -- [Sari, Ismail] Cumhuriyet Univ, Fac Med, Dept Biochem Med, Sivas, Turkey -- [Gumus, Erkan] Cumhuriyet Univ, Fac Med, Dept Histol & Embryol, Sivas, Turkey -- [Yelkovan, Izzet] Cumhuriyet Univ, Fac Med, Dept Med Biol, Sivas, Turkey, SARI, Ismail -- 0000-0001-7737-4180, Elaldi, Nazif -- 0000-0002-9515-770X, Sari, Ismail -- 0000-0003-3732-2102 |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Adolescent Genotype Turkey Polymerase Chain Reaction polymorphism lcsh:Infectious and parasitic diseases Young Adult Gene Frequency Humans lcsh:RC109-216 Crimean-Congo hemorrhagic fever (CCHF) Aged Aged 80 and over IL-6 Polymorphism Genetic Interleukin-6 Tumor Necrosis Factor-alpha Middle Aged Case-Control Studies Hemorrhagic Fever Virus Crimean-Congo Female Hemorrhagic Fever Crimean Polymorphism Restriction Fragment Length TNF-alpha |
| Zdroj: | Journal of Vector Borne Diseases, Vol 52, Iss 1, Pp 30-35 (2015) Scopus-Elsevier |
| ISSN: | 0972-9062 |
| Popis: | WOS: 000355242400004 PubMed ID: 25815864 Objective: In this case-control study, we investigated whether IL-6 (-174G/C) and TNF-alpha (-308G/A) gene polymorphisms affect the clinical course and outcome of CCHF. Methods: Total 150 patients with CCHF and 170 controls were examined in this study. Genotyping of these polymorphisms were performed by PCR-RFLP methods. Results: We found no statistically significant differences in genotype and allele frequencies of these polymorphisms between patients and controls [(chi(2) = 1.31, p = 0.51 for TNF-alpha) and (chi(2)=2.61, p = 0.27 for IL-6)]. Either TNF-alpha AA or IL-6 CC genotypes in dead cases were not observed in this study. Frequency of heterozygous genotypes in both IL-6 (GC) and TNF-alpha (GA) was higher in dead patients than living patients. However, the difference was not statistically significant. A significant difference was found in AST levels and INR when compared to patients with CCHF who died and who survived [OR = 13.9 (95% CI = 1.79-107) for INR, p = 0.01] and [OR = 23.3 (95% CI = 3.62-149) for AST, p = 0.001], respectively. Conclusion: We did not find a significant association of IL-6 -174G/C and TNF-alpha -308G/A polymorphisms on the prognosis of CCHF and mortality in this study. We suggest that AST and INR may be important biomarkers for determining the risk of severity and death as a result of infection with Crimean-Congo hemorrhagic fever virus (CCHFV). Cumhuriyet University Research Committee [T-429] This work was supported by a grant from Cumhuriyet University Research Committee (Project No: T-429) and individual facilities and funds. We used some laboratory facilities in the Research Centre, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. |
| Databáze: | OpenAIRE |
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