Bone geometry, volumetric density, microarchitecture, and estimated bone strength assessed by HR-pQCT in adult patients with hypophosphatemic rickets

Autor: Vikram Vinod Shanbhogue, Stinus Hansen, Lars Folkestad, Kim Brixen, Signe Beck-Nielsen
Rok vydání: 2014
Předmět:
Zdroj: University of Southern Denmark
Shanbhogue, V V, Hansen, S, Folkestad, L, Brixen, K & Beck-Nielsen, S 2015, ' Bone Geometry, Volumetric Density, Microarchitecture and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients with Hypophosphatemic Rickets ', Journal of Bone and Mineral Research, vol. 30, no. 1, pp. 176-183 . https://doi.org/10.1002/jbmr.2310
ISSN: 1523-4681
DOI: 10.1002/jbmr.2310
Popis: Hypophosphatemic rickets (HR) is characterized by a generalized mineralization defect. Although densitometric studies have found the patients to have an elevated bone mineral density (BMD), data on bone geometry and microstructure are scarce. The aim of this cross-sectional in vivo study was to assess bone geometry, volumetric BMD (vBMD), microarchitecture, and estimated bone strength in adult patients with HR using high-resolution peripheral quantitative computed tomography (HR-pQCT). Twenty-nine patients (aged 19 to 79 years; 21 female, 8 male patients), 26 of whom had genetically proven X-linked HR, were matched with respect to age and sex with 29 healthy subjects. Eleven patients were currently receiving therapy with calcitriol and phosphate for a median duration of 29.1 years (12.0 to 43.0 years). Because of the disproportionate short stature in HR, the region of interest in HR-pQCT images at the distal radius and tibia were placed in a constant proportion to the entire length of the bone in both patients and healthy volunteers. In age- and weight-adjusted models, HR patients had significantly higher total bone cross-sectional areas (radius 36%, tibia 20%; both p
Databáze: OpenAIRE
Externí odkaz: