Clinical and histopathological profile of acute renal failure caused by falciparum and vivax monoinfection: an observational study from Bikaner, northwest zone of Rajasthan, India
| Autor: | Kailash Chandra Nayak, Sunil Kumar, Bal Kishan Gupta, Surendra Kumar, Anjli Gupta, Parul Prakash, Dhanpat Kumar Kochar |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Analysis of Variance Acute tubular necrosis malarial acute renal failure mesangioproliferative glomerulonephritis Plasmodium falciparum Plasmodium vivax Adolescent Coinfection India Acute Kidney Injury Middle Aged lcsh:Infectious and parasitic diseases Creatinine Malaria Vivax Humans lcsh:RC109-216 Female Prospective Studies Malaria Falciparum |
| Zdroj: | Journal of Vector Borne Diseases, Vol 51, Iss 1, Pp 40-46 (2014) |
| ISSN: | 0972-9062 |
| Popis: | Background & objectives: Acute renal failure (ARF) is a known manifestation of severe Plasmodium falciparum (Pf) malaria but recently it has also been observed with P. vivax (Pv) monoinfection. A clinical observational study has been conducted to evaluate the clinical and histopathological profile of ARF in malaria. Methods: This study was conducted on 288 consecutive cases of malaria with monoinfection (Pf 191 and Pv 97) diagnosed by peripheral blood film examination and rapid card test. ARF was diagnosed as per WHO criterion (serum creatinine >3 mg%). The data were analysed by Standard t-test using ANOVA software. Results: ARF was seen in 52 cases of Pf and 14 cases of Pv malaria. Mean age was 32.58 yr (ranging 15-65; Pf 33.37 and Pv 29.14) and male to female ratio was 2:1 (Pf 3:1 and Pv 1:1). Most of the cases developed ARF within 10 days of onset of the disease. Associated severe manifestations were jaundice (53 cases: Pf 44 and Pv 9), cerebral malaria (28 cases: Pf 25 and Pv 3), severe anemia (18 cases: Pf 17 and Pv 1), hypotension (16 cases: Pf 11 and Pv 5), bleeding manifestations (16 cases: Pf 14 and Pv 2), multiorgan failure (12 cases: Pf 9 and Pv 3) and ARDS (6 cases: Pf 5 and Pv 1). Kidney biopsy (16 Pf and 2 Pv) showed acute tubular necrosis (5 Pf and 1 Pv), mesangioproliferative glomerulonephritis (2 Pf) or both (9 Pf and 1 Pv). Haemodialysis was done in 7 (Pf 4 and Pv 3) cases, out of which four survived. Most of the cases (48.49%) recovered within two weeks (range 3-20 days). Total mortality was 27.27% (Pf 28.85% and Pv 21.43%). Interpretation & conclusion: ARF can also be caused by vivax monoinfection with similar clinical and histopathological features although outcome is less severe as compared to falciparum monoinfection. |
| Databáze: | OpenAIRE |
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