JCV-specific T-cells producing IFN-gamma are differently associated with PmL occurrence in HIV patients and liver transplant recipients

Autor:	Chiara Agrati, Izzo, L., Berno, G., Cimini, E., Bordoni, V., Giancola, M. L., Baldini, F., Colasanti, M., Ettorre, G. M., Izzo, P., Pugliese, F., Angrisani, M., Di Cello, P., Capobianchi, M. R., Bolognese, A.
Rok vydání:	2014
Předmět:	Adult Male complications isolation & purification etiology T-Lymphocytes HIV Infections Progressive Multifocal HIV Infections complications HIV Infections immunology HIV Infections surgery HIV Infections virology HIV-1 genetics HIV-1 immunology Interferon-gamma genetics Interferon-gamma immunology JC Virus genetics JC Virus immunology JC Virus isolation & purification Leukoencephalopathy Progressive Multifocal etiology Leukoencephalopathy Progressive Multifocal immunology Leukoencephalopathy Progressive Multifocal virology Liver Transplantation T-Lymphocytes immunology T-Lymphocytes virology Transplant Recipients surgery immunology Interferon-gamma Leukoencephalopathy Humans genetics Aged Leukoencephalopathy Progressive Multifocal Middle Aged JC Virus virology HIV-1 Female
Zdroj:	Scopus-Elsevier Europe PubMed Central
ISSN:	1121-7138
Popis:	Aim of this work was to investigate a possible correlation between the frequency of JCV-specific T-cells and PML occurrence in HIV-infected subjects and in liver transplant recipients. A significant decrease of JCV-specific T-cells was observed in HIV-PML subjects, highlighting a close relation between JCV-specific T-cell immune impairment and PML occurrence in HIV-subjects. Interestingly, liver-transplant recipients (LTR) showed a low frequency of JCV-specific T-cells, similar to HIV-PML subjects. Nevertheless, none of the enrolled LTR developed PML, suggesting the existence of different immunological mechanisms involved in the maintenance of a protective immune response in LTR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5a044817969165181fba1b6f8b5dca65 https://pubmed.ncbi.nlm.nih.gov/25742151 Zobrazit plný text záznamu