Hepatoprotective Properties of Aqueous Leaf Extract of Persea Americana, Mill (Lauraceae) ‘Avocado’ Against CCL4-Induced Damage in Rats
| Autor: | Brai, BIC, Adisa, RA, Odetola, AA |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Persea Plant Extracts Superoxide Dismutase Alanine Transaminase Protective Agents Research Papers Glutathione Antioxidants Rats Plant Leaves Liver Persea americana carbon tetrachloride hepatotoxicity lipid peroxidation antioxidants enzymes Malondialdehyde Animals Humans Aspartate Aminotransferases Lipid Peroxidation Chemical and Drug Induced Liver Injury Rats Wistar Carbon Tetrachloride |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines; Vol 11, No 2 (2014); 237-244 |
| ISSN: | 0189-6016 |
| Popis: | Background: Natural products from plants have received considerable attention in recent years due to their diverse pharmacological properties,including antioxidants and hepatoprotective activities. The protective effects of aqueous extract of Persea americana (AEPA) against carbon tetrachloride (CCl4)-induced hepatotoxicity in male albino rats was investigated. Materials and Methods: Liver damage was induced in rats by administering a 1:1 (v/v) mixture of CCl4 and olive oil [3 ml/kg, subcutaneously (sc)] after pre-treatment for 7 days with AEPA. Hepatoprotective effects of AEPA was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and levels of total bilirubin (TBL). The effects of AEPA on biomarkers of oxidative damage (lipid peroxidation) and antioxidant enzymes namely, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase (GST) were measured in liver post mitochondrial fraction.Results: AEPA and Reducdyn® showed significant (p |
| Databáze: | OpenAIRE |
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