Nitric oxide levels during erythroid differentiation in K562 cell line
| Autor: | Kucukkaya, B., Ozturk, G., Yalcintepe, L. |
|---|---|
| Přispěvatelé: | Maltepe Üniversitesi |
| Rok vydání: | 2006 |
| Předmět: |
Erythrocytes
Nitrates ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Nitric oxide Cell Differentiation Nitric Oxide Biochemistry K562 cell line Cell Line ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS Hemoglobins ComputingMethodologies_PATTERNRECOGNITION Hemin Humans InformationSystems_MISCELLANEOUS K562 Cells Erythroid differentiation Nitrites Software |
| Zdroj: | Indian journal of biochemistrybiophysics. 43(4) |
| ISSN: | 0301-1208 |
| Popis: | WOS: 000240011500009 PubMed ID: 17133771 Nitric oxide (NO) is endogenous mediator of numerous physiological processes that range from regulation of cardiovascular function and neurotransmission to antipathogenic and tumoricidal responses. This study was designed to investigate the possible role of NO during erythroid differentiation in K562 erythroleukemia cells. The chronic myelogenous leukemia (K562) cell line call be triggered in culture to differentiate along the erythrocytic pathway, in response to a variety of stimulatory agents. In this study, K562 cells were induced to synthesize hemoglobin by hemin. We investigated NOx (nitrate+nitrite) levels in uninduced (control) and hemin-induced K562 cell lysates during erythroid differentiation. Our results showed that NO levels decreased significantly oil fourth and sixth day both in hemin-induced and control cells; the decrease was, however, more in hemin-induced group than in control group. |
| Databáze: | OpenAIRE |
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