Impact of disease stage and aetiology on survival in hepatocellular carcinoma: implications for surveillance
| Autor: | Johnson, Philip, Berhane, Sarah, Kagebayashi, Chiaki, Satomura, Shinji, Teng, Mabel, Fox, Richard, Yeo, Winnie, Mo, Frankie, Lai, Paul, Chan, Stephen L, Tada, Toshifumi, Toyoda, Hidenori, Kumada, Takashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
hepatitis C virus
Male Carcinoma Hepatocellular aetiology geographical variation Liver Neoplasms hepatocellular carcinoma Middle Aged Hepatitis B Hepatitis C Survival Analysis Japan Epidemiological Monitoring Clinical Study surveillance Hong Kong Humans Female hepatitis B virus Aged Neoplasm Staging |
| Zdroj: | British Journal of Cancer |
| Popis: | Background: Variation in survival in hepatocellular carcinoma (HCC) has been attributed to different aetiologies or disease stages at presentation. While international guidelines recommend surveillance of high-risk groups to permit early diagnosis and curative treatment, the evidence that surveillance decreases disease-specific mortality is weak. Methods: We compared HCC survival figures from Japan (n=1174) and Hong Kong (n=1675) over similar time periods (Japan 2000–2013, Hong Kong, China 2003–2014). The former has an intensive national surveillance programme, while the latter has none. We also analysed changes in survival in Japan over a 50-year period including data from before and after institution of a national HCC surveillance programme. Results: In Japan, over 75% of cases are currently detected by surveillance, whereas in Hong Kong |
| Databáze: | OpenAIRE |
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