Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community-Based Cohort Studies
| Autor: | Lisan, Q., van Sloten, T., Boutouyrie, P., Laurent, S., Danchin, N., Thomas, F., Guibout, C., Perier, M.C., Dagnelie, P., Henry, R.M., Schram, M.T., Heinzer, R., Marques-Vidal, P., van der Kallen, C.J., Crijns, H.J., van Greevenbroek, M., Reesink, K., Köhler, S., Sastry, M., Jouven, X., Stehouwer, CDA, Empana, J.P. |
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| Přispěvatelé: | Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), Biomedische Technologie, RS: Carim - H07 Cardiovascular System Dynamics, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Interne Geneeskunde (3) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Aging Epidemiology POSITIVE AIRWAY PRESSURE Carotid Intima-Media Thickness Risk Assessment INTIMA-MEDIA THICKNESS DISEASE PULSE-WAVE Vascular Stiffness community‐based study sleep apnea vascular aging Prevalence Humans Correlation of Data Ultrasonography Original Research RISK Sleep Apnea Obstructive AORTIC STIFFNESS Middle Aged community-based study EARLY SIGNS Europe ATHEROSCLEROSIS Cardiovascular Diseases Heart Disease Risk Factors Carotid-Femoral Pulse Wave Velocity Female BERLIN QUESTIONNAIRE FOLLOW-UP |
| Zdroj: | Journal of the American Heart Association, 10(15):021318. Wiley Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease Journal of the American Heart Association, vol. 10, no. 15, pp. e021318 |
| ISSN: | 2047-9980 |
| Popis: | Background The mechanisms underlying the association between obstructive sleep apnea (OSA) and cardiovascular disease may include accelerated vascular aging. The aim was to compare the magnitude of vascular aging in patients with high versus low risk of OSA. Methods and Results In 2 community-based studies, the PPS3 (Paris Prospective Study 3) and the Maastricht Study, high risk of OSA was determined with the Berlin questionnaire (a screening questionnaire for OSA). We assessed carotid artery properties (carotid intima-media thickness, Young's elastic modulus, carotid-femoral pulse wave velocity, carotid pulse wave velocity, carotid diameter using high precision ultrasound echography), and carotid-femoral pulse wave velocity (in the Maastricht Study only). Regression coefficients were estimated on pooled data using multivariate linear regression. A total of 8615 participants without prior cardiovascular disease were included (6840 from PPS3, 62% men, mean age 59.5 +/- 6.2 years, and 1775 from the Maastricht Study, 51% men, 58.9 +/- 8.1 years). Overall, high risk of OSA prevalence was 16.8% (n=1150) in PPS3 and 23.8% (n=423) in the Maastricht Study. A high risk of OSA was associated with greater carotid intima-media thickness (beta=0.21; 0.17-0.26), Young's elastic modulus (beta=0.21; 0.17-0.25), carotid-femoral pulse wave velocity (beta=0.24; 0.14-0.34), carotid pulse wave velocity (beta=0.31; 0.26-0.35), and carotid diameter (beta=0.43; 0.38-0.48), after adjustment for age, sex, total cholesterol, smoking, education level, diabetes mellitus, heart rate, and study site. Consistent associations were observed after additional adjustments for mean blood pressure, body mass index, or antihypertensive medications. Conclusions These data lend support for accelerated vascular aging in individuals with high risk of OSA. This may, at least in part, underlie the association between OSA and cardiovascular disease. |
| Databáze: | OpenAIRE |
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