Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism

Autor: Guillaume, Dumas, Hany, Goubran-Botros, Mariette, Matondo, Cécile, Pagan, Cyril, Boulègue, Thibault, Chaze, Julia, Chamot-Rooke, Erik, Maronde, Thomas, Bourgeron
Přispěvatelé: Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Precision Psychiatry and Social Physiology laboratory [Montreal] (PPHP), CRSN/Faculté de médecine Université de Montréal-CHU Sainte Justine [Montréal], Spectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology (UTechS MSBio), Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Sorbonne Paris Cité (USPC), Service de Biochimie et de Biologie Moléculaire [AP-HP Hôpital Lariboisière] (Inserm U942), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Anatomy II, Goethe-Universität Frankfurt am Main, This work was supported by the Institut Pasteur, the CNRS, the INSERM, the AP-HP, the University Paris Diderot, the Cognacq-Jay foundation, the Bettencourt-Schueller foundation, the Orange foundation, the FondaMental foundation, the Fondation de France, the Conny-Maeva foundation, the Eranet-Neuron ANR (ALTRUISM), and the Labex GenMed and BioPsy. GD is funded by the Institute for Data Valorization (IVADO), Montreal, and the Fonds de recherche du Québec (FRQ)., ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), ANR-10-LABX-0013,GENMED,Medical Genomics(2010), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut Pasteur [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), PORTELETTE, Virginie, Sorbonne Universités à Paris pour l'Enseignement et la Recherche - - SUPER2011 - ANR-11-IDEX-0004 - IDEX - VALID, Medical Genomics - - GENMED2010 - ANR-10-LABX-0013 - LABX - VALID
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Pineal Research
Journal of Pineal Research, 2020, 70, ⟨10.1111/jpi.12713⟩
Journal of Pineal Research, Wiley, 2020, 70, ⟨10.1111/jpi.12713⟩
ISSN: 0742-3098
1600-079X
Popis: International audience; The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day, and, compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane‐bounded vesicle‐related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.
Databáze: OpenAIRE
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