Effect of wine ethanol on serum iron and ferritin levels in patients with coronary heart disease
| Autor: | De Lorgeril, M., Salen, P., De Leiris, J., Boucher, François, Paillard, F. |
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| Přispěvatelé: | Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Salen, Patricia |
| Rok vydání: | 2001 |
| Předmět: |
MESH: Aged
MESH: Iron MESH: Ethanol MESH: Humans Alcohol Drinking Ethanol Iron MESH: Ferritins Central Nervous System Depressants Coronary Disease Wine MESH: Follow-Up Studies MESH: Single-Blind Method MESH: Wine [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Ferritins Humans Single-Blind Method MESH: Coronary Disease MESH: Central Nervous System Depressants [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition MESH: Alcohol Drinking Aged Follow-Up Studies |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases Nutrition, Metabolism and Cardiovascular Diseases, Elsevier, 2001, 11 (3), pp.176-80 |
| ISSN: | 0939-4753 |
| Popis: | International audience; BACKGROUND AND AIM: The association between high body iron stores and coronary heart disease (CHD) is a subject of intense debate whereas wine consumption is known to be associated with a low CHD rate. It has been suggested that the inhibition of iron absorption is one of the possible mechanisms of the CHD-protective effects of drinking. METHODS AND RESULTS: We analysed the interrelationships of wine ethanol intake and fasting serum ferritin, iron and gamma glutamyl transferase (GGT) in patients enrolled in the Lyon Diet Heart Study, a secondary prevention trial designed to test whether a Mediterranean-type diet may protect against CHD. The intake of wine ethanol was evaluated in the 24 hours preceding blood sampling, and expressed as a percentage of the total daily energy intake. Data were obtained from 437 consecutive patients. There was a positive relationship (Spearman statistics) between wine ethanol and the serum levels of iron (r = 0.21, p < 0.0001), ferritin (r = 0.23, p < 0.0001) and GGT (r = 0.31, p < 0.0001). Uni- and multilinear regression analyses after excluding non-drinkers and log transforming the variables yielded similar results. CONCLUSIONS: The available data showing positive relationships between wine ethanol intake and serum concentrations of both ferritin and iron in patients with CHD tend to disprove the hypothesis that wine ethanol consumption could decrease iron stores and thereby the risk of CHD. Further studies are required to investigate the mechanism(s) by which wine drinking reduces the risk of CHD. |
| Databáze: | OpenAIRE |
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