Limited uptake of ulcerative colitis 'treat-to-target' recommendations in real-world practice

Autor:	Bryant, RV, Costello, SP, Schoeman, S, Sathananthan, D, Knight, E, Lau, SY, Schoeman, MN, Mountifield, R, Tee, D, Travis, SPL, Andrews, JM
Rok vydání:	2017
Předmět:	Adult Male Remission Induction Middle Aged Endoscopy Gastrointestinal C-Reactive Protein Cross-Sectional Studies Logistic Models Practice Guidelines as Topic Humans Multicenter Studies as Topic Colitis Ulcerative Female Biomarkers Retrospective Studies
Zdroj:	Journal of gastroenterology and hepatology. 33(3)
ISSN:	1440-1746
Popis:	A 'Treat to Target' (T2T) approach has been proposed for ulcerative colitis (UC), with a target of combined clinical and endoscopic remission. The aim of the study was evaluate the extent to which proposed targets are achieved in real-world care, along with clinician perceptions and potential challenges.A multicentre, retrospective, cross-sectional review of patients with UC attending outpatient services in South Australia was conducted. Clinical and objective assessment of disease activity (endoscopy, histology, and/or biomarkers) was recorded. A survey evaluated Gastroenterologists' perceptions of T2T in UC. Statistical analysis included logistic regression and Fisher's exact tests.Of 246 patients with UC, 61% were in clinical remission (normal bowel habit and no rectal bleeding), 35% in clinical and endoscopic remission (Mayo endoscopic sub-score ≤1), and 16% in concordant clinical, endoscopic and histological (Truelove and Richards' Index) remission. Rather than disease-related factors (extent/activity), clinician-related factors dominated outcome. Hospital location and the choice of therapy predicted combined clinical and endoscopic remission (OR 3.6, 95% CI 1.6-8.7, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::572c78318c64d633108ad881e5775f2c https://pubmed.ncbi.nlm.nih.gov/28806471 Zobrazit plný text záznamu Plný text