Classifying the Binding Modes of Disordered Proteins
| Autor: | Fuxreiter, M. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Protein Folding Molecular conformational heterogeneity Review context-dependence Condensed Matter::Disordered Systems and Neural Networks fuzzy binding Quantitative Biology::Subcellular Processes Intrinsically Disordered Proteins lcsh:Chemistry lcsh:Biology (General) lcsh:QD1-999 Models disordered protein Conformational heterogeneity Context-dependence Disordered protein Fuzzy binding Protein interaction protein interaction lcsh:QH301-705.5 |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 8615, p 8615 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Disordered proteins often act as interaction hubs in cellular pathways, via the specific recognition of a distinguished set of partners. While disordered regions can adopt a well-defined conformation upon binding, the coupled folding to binding model does not explain how interaction versatility is achieved. Here, I present a classification scheme for the binding modes of disordered protein regions, based on their conformational heterogeneity in the bound state. Binding modes are defined as (i) disorder-to-order transitions leading to a well-defined bound state, (ii) disordered binding leading to a disordered bound state and (iii) fuzzy binding when the degree of disorder in the bound state may vary with the partner or cellular conditions. Fuzzy binding includes polymorphic bound structures, conditional folding and dynamic binding. This classification scheme describes the structural continuum of complexes involving disordered regions as well as their context-dependent interaction behaviors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|