Comparison of histopathologic classification and surgical stage by cytokeratin 8 and cytokeratin 18 in endometrial cancer

Autor:	Kabukcuoglu S, Ss, Ozalp, Omer Tarik Yalcin, Colak E, Aa, Abubakar
Předmět:	Keratin-18 Keratin-8 Middle Aged Prognosis Immunohistochemistry Endometrial Neoplasms Lymphatic Metastasis Disease Progression Humans Female Neoplasm Invasiveness Prospective Studies Aged Neoplasm Staging
Zdroj:	Scopus-Elsevier Europe PubMed Central
Popis:	The aim of the study was to show the role of the cytoskeletal proteins CK8 and CK18 in endometrial cancer invasion and to histopathologically classify endometrial cancer patients.This study was a prospective analysis of 49 histologic samples of consecutively surgically operated endometrial cancer patients. After histopathologic classification the most invasive tumor area was selected for immunohistochemistry. Monoclonal antihuman keratin Ab-4 and keratin Ab-1 were applied.CK8 and CK18 stained tumoral tissue and tumoral cell debris in the lymphovascular space were significantly correlated with stage (por = 0.005).To understand the causes of early treatment failure in endometrial cancer patients, further studies are needed to show the role of enhancing factors of endometrial cancer invasion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::557466b1c0623b5afd6dba7acd11174e http://www.scopus.com/inward/record.url?eid=2-s2.0-78751538200&partnerID=MN8TOARS Zobrazit plný text záznamu