Linear IgA Bullous Dermatosis: A Series of 17 Cases
| Autor: | M S, Díaz, L, Morita, B, Ferrari, S, Sartori, M F, Greco, L, Sobrevias Bonells, M A, González-Enseñat, M A, Vicente Villa, M, Larralde |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Chronic bullous dermatosis of childhood Dermatosis ampollar IgA lineal Dermatosis ampollar crónica de la infancia IgA lineal Linear IgA Linear IgA bullous dermatosis integumentary system Infant Linear IgA Bullous Dermatosis Adrenal Cortex Hormones Fluorescent Antibody Technique Direct Child Preschool Humans Female Dermatologic Agents Child Dapsone Retrospective Studies |
| Zdroj: | ACTAS DERMO-SIFILIOGRAFICAS r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname |
| ISSN: | 0001-7310 |
| Popis: | Linear IgA bullous dermatosis is an acquired subepidermal immunoglobulin-mediated vesiculobullous disease. In this retrospective, observational, descriptive study, we describe the clinical characteristics, treatments, and outcomes of 17 patients with linear IgA bullous dermatosis. Two children had been vaccinated 2 weeks before the onset of symptoms, 2 had had bronco-obstructive respiratory symptoms, and 1 had received intravenous antibiotic therapy. We also observed an association with autoimmune hepatitis in one patient and alopecia areata in another. One boy had VACTERL association. Diagnosis was confirmed by histopathology and direct immunofluorescence. Sixteen patients were treated with dapsone, which was combined with oral corticosteroids in 8 cases and topical corticosteroids in two. Of note in this series was the occurrence of relapses in the perioral area coinciding with infections and vaccination, and the association between linear IgA bullous dermatosis and autoimmune hepatitis and VACTERL association. |
| Databáze: | OpenAIRE |
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