Demyelinating and gliotic cerebellar lesions in Langerhans cell histiocytosis
| Autor: | L B, Poe, R L, Dubowy, L, Hochhauser, G H, Collins, C J, Crosley, M D, Kanzer, M, Oliphant, C J, Hodge |
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| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Male
Neurologic Examination Biopsy Histiocytes Magnetic Resonance Imaging Histiocytosis Langerhans-Cell Cerebellar Nuclei Cerebellar Diseases Cerebellum Child Preschool Journal Article Humans Female Gliosis Prospective Studies Child Tomography X-Ray Computed Myelin Sheath Demyelinating Diseases Retrospective Studies |
| Zdroj: | AJNR Am J Neuroradiol |
| Popis: | PURPOSE: To describe the involvement of the cerebellum by a gliotic and demyelinating process in Langerhans cell histiocytosis. METHODS: A retrospective analysis of all (N = 30) cases of Langerhans cell histiocytosis followed at our institution since 1975 yielded four patients with CT and/or MR evidence of cerebellar abnormalities. RESULTS: Four patients manifested strikingly similar findings of symmetric nonenhancing hypodensities in the dentate nuclei region of the cerebellum, which were hypointense on short-repetition-time/short-echo-time MR and hyperintense on long-repetition-time/long-echo-time MR. Biopsy in one patient yielded areas of demyelination, cell loss, and gliosis without histiocytic infiltration. CONCLUSION: Langerhans cell histiocytosis involves the cerebellum in a specific and poorly understood manner. Lesions on imaging may precede clinical findings by years. Lesions may occur in patients who have never experienced radiation therapy and may act as a marker for eventual central nervous system deterioration. |
| Databáze: | OpenAIRE |
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