Hyperthermic intraperitoneal intraoperative chemotherapy for peritoneal carcinomatosis arising from gastric adenocarcinoma

Autor:	Carlo Riccardo Rossi, Pilati P, Mocellin S, Foletto M, Ori C, Innocente F, Nitti D, Lise M
Jazyk:	angličtina
Rok vydání:	2003
Předmět:	Adult Male Mitomycin Hyperthermia Induced Adenocarcinoma Middle Aged Survival Analysis Treatment Outcome Stomach Neoplasms Antineoplastic Combined Chemotherapy Protocols Humans Female Infusions Parenteral Cisplatin Peritoneal Neoplasms Aged
Zdroj:	Scopus-Elsevier ResearcherID Europe PubMed Central
Popis:	Patients with peritoneal carcinomatosis from gastric carcinoma have a dismal prognosis. Hyperthermic intraperitoneal intraoperative chemotherapy (HIIC) has been proposed to treat residual disease after cytoreductive surgery.From January 1998 through July 2002, 13 patients with peritoneal carcinomatosis from gastric cancer underwent complete cytoreductive surgery followed by HIIC. Chemo-hyperthermia was performed using mitomicin C (3.3 mg/m2) and cisplatin (25 mg m2) for 90 minutes, at a mean intraperitoneal temperature of 41.7 degrees C.No postoperative death was observed. Moderate locoregional toxicity (ileus) was observed in eight cases (42%), while two patients (10%) experienced mild systemic toxicity (myelosuppression or fever). Postoperative complication rate was 26% (pleural effusion, n = 4; septicemia = 1). Median overall survival was 15 months, and the median local progression free survival was 10 months.Cytoreductive surgery followed by HIIC resulted a feasible procedure, the overall morbidity rate being acceptable. Although the study was conducted in a subset of patients with peritoneal carcinomatosis from gastric cancer (resectable disease), survival results are encouraging.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::54bb3175fac7b9613ab025e1e3d6406c http://hdl.handle.net/11577/2461636 Zobrazit plný text záznamu