Cognitive profile of LRRK2-related Parkinson's disease
| Autor: | Srivatsal, S, Cholerton, B, Leverenz, JB, Wszolek, ZK, Uitti, RJ, Dickson, DW, Weintraub, D, Trojanowski, JQ, Van Deerlin, VM, Quinn, JF, Chung, KA, Peterson, AL, Factor, SA, Wood-Siverio, C, Goldman, JG, Stebbins, GT, Bernard, B, Ritz, B, Rausch, R, Espay, AJ, Revilla, FJ, Devoto, J, Rosenthal, LS, Dawson, TM, Albert, MS, Mata, IF, Hu, SC, Montine, KS, Johnson, C, Montine, TJ, Edwards, KL, Zhang, J, Zabetian, CP |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male cognition neuropsychological tests Aging Parkinson's disease Clinical Sciences Neuropsychological Tests Protein Serine-Threonine Kinases Neurodegenerative Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Article working memory Cohort Studies 80 and over Genetics Acquired Cognitive Impairment Humans 2.1 Biological and endogenous factors Genetic Testing Aetiology Aged Aged 80 and over Neurology & Neurosurgery Neurosciences Parkinson Disease LRRK2 Human Movement and Sports Sciences Middle Aged Brain Disorders nervous system diseases Cross-Sectional Studies Good Health and Well Being Mutation Neurological Cognitive Sciences Female Dementia Cognition Disorders Mental Status Schedule |
| Zdroj: | Srivatsal, S; Cholerton, B; Leverenz, JB; Wszolek, ZK; Uitti, RJ; Dickson, DW; et al.(2015). Cognitive profile of LRRK2-related Parkinson's disease. Movement Disorders, 30(5), 728-733. doi: 10.1002/mds.26161. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7ds270r7 Movement disorders : official journal of the Movement Disorder Society, vol 30, iss 5 Movement Disorders, vol 30, iss 5 |
| Popis: | © 2015 International Parkinson and Movement Disorder Society. Background: Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized. Methods: A cohort of 1,447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for LRRK2 mutations and completed detailed cognitive testing. Associations between mutation carrier status and cognitive test scores were assessed using linear regression models. Results: LRRK2 mutation carriers (n=29) demonstrated better performance on the Mini Mental State Examination (P=0.03) and the Letter-Number Sequencing Test (P=0.005). A smaller proportion of LRRK2 carriers were demented (P=0.03). Conclusions: Our cross-sectional study demonstrates better performance on certain cognitive tests, as well as lower rates of dementia in LRRK2-related PD. Future longitudinal studies are needed to determine whether LRRK2 mutation carriers exhibit slower cognitive decline. |
| Databáze: | OpenAIRE |
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