Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Autor: Thijssen, Victor LJL, Paulis, Yvette WJ, Nowak-Sliwinska, Patrycja, Deumelandt, Katrin L, Hosaka, Kayoko, Soetekouw, Patricia MMB, Cimpean, Anca M, Raica, Marius, Pauwels, Patrick, van den Oord, Joost J, Tjan-Heijnen, Vivianne CG, Hendrix, Mary J, Heldin, Carl-Henrik, Cao, Yihai, Griffioen, Arjan W
Přispěvatelé: Promovendi ODB, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), Medical oncology laboratory, Radiation Oncology, VU University medical center, CCA - Cancer biology and immunology
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Time Factors
perivascular cells
Cell Communication/drug effects
TO-MESENCHYMAL TRANSITION
Melanoma
Experimental
vessel stabilization
Cell Communication
STEM-LIKE CELLS
Cell Proliferation/drug effects
Mice
Antineoplastic Agents
Immunological
Signal Transduction/drug effects
Pathology
IN-VIVO
Platelet-Derived Growth Factor
ddc:615
CO-OPTION
Neovascularization
Pathologic
Biological Mimicry
Original Papers
endothelial cells
Antineoplastic Agents
Immunological/pharmacology
Tumor Burden
VASCULOGENIC MIMICRY
Oncology
PRIMARY CUTANEOUS MELANOMA
Imatinib Mesylate
Imatinib Mesylate/pharmacology
Life Sciences & Biomedicine
Tumor Burden/drug effects
Platelet-Derived Growth Factor/antagonists & inhibitors/immunology/metabolism
Signal Transduction
Mice
Nude
Cell Line
Tumor
melanoma
Animals
Humans
cancer
BREAST-CANCER
Protein Kinase Inhibitors
Cell Proliferation
Biological Mimicry/drug effects
Original Paper
Science & Technology
Melanoma
Experimental/blood supply/drug therapy/metabolism/pathology
tumor angiogenesis
Pericytes/drug effects/metabolism/pathology
Xenograft Model Antitumor Assays
ENDOTHELIAL-CELLS
Coculture Techniques
imatinib
Protein Kinase Inhibitors/pharmacology
METASTASIS
Human medicine
Pericytes
Ewing sarcoma
ANTI-ANGIOGENIC THERAPY
Zdroj: Thijssen, V L J L, Paulis, Y W J, Nowak-Sliwinska, P, Deumelandt, K L, Hosaka, K, Soetekouw, P M M B, Cimpean, A M, Raica, M, Pauwels, P, van den Oord, J J, Tjan-Heijnen, V C G, Hendrix, M J, Heldin, C-H, Cao, Y & Griffioen, A W 2018, ' Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth ', Journal of Pathology, vol. 246, no. 4, pp. 447-458 . https://doi.org/10.1002/path.5152
Journal of Pathology, 246(4), 447-458. Wiley
The Journal of Pathology
Journal of Pathology, 246(4), 447-458. John Wiley and Sons Ltd
The Journal of Pathology, Vol. 246, No 4 (2018) pp. 447-458
The journal of pathology
ISSN: 0022-3417
DOI: 10.1002/path.5152
Popis: Aggressive tumor cells can adopt an endothelial cell-like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis. This adoptive mechanism is referred to as vascular mimicry and it is associated with poor survival in cancer patients. To what extent tumor cells capable of vascular mimicry phenocopy the angiogenic cascade is still poorly explored. Here, we identify pericytes as important players in vascular mimicry. We found that pericytes are recruited by vascular mimicry-positive tumor cells in order to facilitate sprouting and to provide structural support of the vascular-like networks. The pericyte recruitment is mediated through platelet-derived growth factor (PDGF)-B. Consequently, preventing PDGF-B signaling by blocking the PDGF receptors with either the small tyrosine kinase inhibitor imatinib or blocking antibodies inhibits vascular mimicry and tumor growth. Collectively, the current study identifies an important role for pericytes in the formation of vascular-like structures by tumor cells. Moreover, the mechanism that controls the pericyte recruitment provides therapeutic opportunities for patients with aggressive vascular mimicry-positive cancer types. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ispartof: JOURNAL OF PATHOLOGY vol:246 issue:4 pages:447-458 ispartof: location:England status: published
Databáze: OpenAIRE
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