Sex-specific associations of obesity and N-Terminal Pro-B-Type Natriuretic Peptide levels in the general population
| Autor: | Suthahar, Navin, Meijers, Wouter C, Ho, Jennifer E, Gansevoort, Ron T, Voors, Adriaan A, van der Meer, Peter, Bakker, Stephan J L, Heymans, Stephane, van Empel, Vanessa, Schroen, Blanche, van der Harst, Pim, van Veldhuisen, Dirk J, de Boer, Rudolf A |
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| Přispěvatelé: | Cardiologie, RS: CARIM - R2.02 - Cardiomyopathy, MUMC+: MA Med Staf Spec Cardiologie (9), Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cardiac & Cardiovascular Systems BIOMARKERS Article Body Mass Index Sex Factors Age Females Risk Factors TESTOSTERONE Natriuretic Peptide Brain Humans Prospective Studies cardiovascular diseases Obesity Sex Distribution Netherlands RISK Heart Failure Science & Technology Incidence Males WOMEN Middle Aged Prognosis Peptide Fragments BODY-MASS INDEX ADIPOSE-TISSUE NT-proBNP CARDIOVASCULAR-DISEASE Population Surveillance ABDOMINAL OBESITY Cardiovascular System & Cardiology HEART-FAILURE Sex Female Life Sciences & Biomedicine WAIST CIRCUMFERENCE hormones hormone substitutes and hormone antagonists Follow-Up Studies |
| Zdroj: | European journal of heart failure, 20(8), 1205-1214. Wiley European Journal of Heart Failure, 20(8), 1205-1214. Wiley |
| ISSN: | 1388-9842 |
| Popis: | BACKGROUND: Obese subjects have lower natriuretic peptide levels, but males and females have different anthropometric characteristics and fat distribution. Whether obesity-associated lowering of natriuretic peptides differs among males and females is unknown. Therefore, we investigated sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels among adults in the general population. METHODS AND RESULTS: Using 8260 participants (50.1% females) from the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort, we evaluated the relationship of NT-proBNP levels with obesity-associated parameters, i.e. waist circumference (WC), body mass index (BMI) and body weight in the overall population, and in males and females separately. NT-proBNP levels were higher in females (median, interquartile range: 50.5, 28.2-87.0 ng/L) than in males (24.3, 10.1-54.6 ng/L; P |
| Databáze: | OpenAIRE |
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