[Association between viral infections and post-transplant malignancies in renal transplant recipients]
| Autor: | NIKOLINA BAŠIĆ-JUKIĆ, LJUBICA BUBIĆ-FILIPI, VESNA LOVČIĆ, IVA RATKOVIĆ, PETAR KES |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske Volume 65 Issue 4 |
| ISSN: | 1330-0164 1848-8897 |
| Popis: | Uporaba imunosupresijskih lijekova povezuje se s povećanom učestalosti različitih zloćudnih bolesti. Etiologija posttransplantacijskih zloćudnih bolesti je multifaktorska te uključuje i oslabljen imunološki odgovor na različite virusne infekcije, neodgovarajuće uklanjanje oštećenih stanica, kao i oslabljenu mogućnost popravka lomova DNK. Među viruse koji se povezuju s pojavom tumora nakon transplantacije bubrega ubrajaju see EBV, HHV-8, virus Merkelovih stanica, virusi hepatitisa B i C, te BK virus. CMV se povezuje s karcinomom debelog crijeva. Dosadašnje se spoznaje uglavnom temelje na pojedinačnim slučajevima opisanima u literaturi. Potrebna su daljnja istraživanja kojima bi se potvrdila povezanost virusnih infekcija s razvojem tumora nakon transplantacije bubrega. Immunosuppressive treatment is associated with an increased incidence of different malignant diseases. The etiology of posttransplant malignancies is multifactorial and includes decreased immune response to different viral infections, inappropriate removal of damaged cells, and impaired ability to repair DNA. EBV, HHV-8, Merkel cell virus, hepatitis B virus, hepatitis C virus and BK virus are all considered to be involved in the etiology of post-transplant malignancies. CMV has been considered as a potential causative factor in the development of colon cancer. However, current knowledge is mainly based on case reports. Further studies are needed to establish the causative role of different viruses in the etiology and pathogenesis of different malignant diseases in renal transplant population. |
| Databáze: | OpenAIRE |
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