| Autor: |
Boner, Al, Vallone, G, Valletta, E, Bernocchi, D, Plebani, Mario |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology research. 7(5) |
| ISSN: |
0251-1649 |
| Popis: |
Theophylline level variability obtained with standard slow-release theophylline tablets was compared to that obtained with a new sustained-release theophylline suspension in asthmatic children. The sustained-release preparations were administered every 12 hours and serum samples were collected after ten days of treatment during the steady-state period. In this crossover study, the sequence of the two regimens (slow-release tablets versus slow-release suspension) was selected at random. Both preparations of theophylline were administered at a mean dosage (+/- s.d.) of 19.3 +/- 1 mg/kg/day. The results of our study demonstrated that theophylline serum levels remain within the therapeutic range for both preparations, but there was a greater fluctuation with theophylline suspension compared to the tablets. The tolerability of the two drugs was satisfactory. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
