Effect of Panax ginseng on Carbamazepine Pharmacokinetics in Rabbits
| Autor: | Issam Mohammed ABUSHAMMALA, Fatma Khaled EL-SHAIKH ALI, Kamal Fakher ABU SHAMMALEH, Mohammed Mahmoud TAHA, Mohammed Yousef MIQDAD |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Turk J Pharm Sci Turkish Journal of Pharmaceutical Sciences, Vol 18, Iss 1, Pp 17-20 (2021) |
| Popis: | OBJECTIVES: Carbamazepine (CBZ) is a well-known drug prescribed to treat epilepsy and the preferred drug for trigeminal neuralgia. This study was conducted to investigate the effect of Panax ginseng extract (PGE) on the disposition of CBZ, a CYP3A4 substrate, in rabbits. MATERIALS AND METHODS: An in vivo randomized parallel design was used to examine herb-drug interactions in 12 male rabbits distributed into 2 groups. In the 1(st) group (control group), 6 rabbits (control group) were administered orally with CBZ suspension (30 mg/kg/day) as a single daily dose for 10 days. In the 2(nd) group (test group), 6 rabbits was treated concomitantly with CBZ and a dose of PGE (2.5 mg/kg/day) at the same time as in the 1(st) group. Blood samples were withdrawn from the marginal ear vein of the rabbits at intervals of 0.0, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 4.0, 6.0, 12.0, and 24.0 h. RESULTS: CBZ had no significantly different pharmacokinetic (PK) parameters, namely, C(max), t(max), AUC(0-24), AUC(0-∞), t(½), and K(e), when it was given alone or concurrently with PGE (p≥0.05). CONCLUSION: PGE may unlikely interfere with the PK of CBZ when it is co-administered with CBZ. Therefore, PGE can be used safely without precautions or dose monitoring. |
| Databáze: | OpenAIRE |
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