Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice
| Autor: | Ducournau, Céline, Nguyen, Thi Thanh Loi, Carpentier, Rodolphe, Lantier, Isabelle, Germon, Stéphanie, Précausta, Flavien, Pisella, Pierre-Jean, Leroux, Hervé, van Langendonck, Nathalie, Betbeder, Didier, Dimier-Poisson, Isabelle |
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| Přispěvatelé: | Infectiologie Animale et Santé Publique - IASP (Nouzilly, France), Institut National de la Recherche Agronomique (INRA), UMR 995, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lille, Droit et Santé, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université d'Artois (UA), Infectiologie Santé Publique (ISP-311), Université de Tours-Institut National de la Recherche Agronomique (INRA), Service de Parasitologie-Mycologie-Médecine Tropicale, CHRU Bretonneau, French ANR (Agence Nationale de la Recherche) ANR-12-EMMA-0032-02, Hanoi Institute of Biotechnology, Vietnamese Government, Institut National de la Recherche Agronomique (INRA)-Université de Tours, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Protozoan Vaccines
Vaccines Synthetic vaccin mice nanoparticle Microbiology and Parasitology nasal vaccination public health toxoplasmose congenitale souris nanoparticule Microbiologie et Parasitologie Toxoplasmosis Congenital Disease Models Animal [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology congenital toxoplasmosis santé publique vaccine parasite Animals nanoparticles Administration Intranasal |
| Zdroj: | Future Microbiology Future Microbiology, Future Medicine, 2017, 12 (5), pp.393-405. ⟨10.2217/fmb-2016-0146⟩ Future Microbiology 5 (12), 393-405. (2017) Future Microbiology, 2017, 12 (5), pp.393-405. ⟨10.2217/fmb-2016-0146⟩ |
| ISSN: | 1746-0913 1746-0921 |
| Popis: | International audience; Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied. Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine. |
| Databáze: | OpenAIRE |
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