[The Italian Registry of Bone Marrow Donors: genetic structure and recruitment strategy]

Autor:	Rendine, Sabina, Barbanti, M., Borelli, Iolanda, Dall'Omo, Am, Roggero, S., Sacchi, N., Curtoni, Es
Rok vydání:	2000
Předmět:	HLA bone marrow Genotype HLA-A Antigens Italy Bone Marrow HLA-B Antigens Histocompatibility Testing Humans HLA-DR Antigens Registries Algorithms
Zdroj:	Annali dell'Istituto superiore di sanita. 35(1)
ISSN:	0021-2571
Popis:	The genetic structure of the Italian bone marrow donor population was analysed by estimating the HLA-A, -B and -DR gene and haplotype frequencies for the total population and for the Italian administrative regions. The haplotype frequencies were used to predict the probability of finding HLA-compatible donors for Italian patients depending on the registry size, and the probability of recruiting in the different Italian regions a donor with a new phenotype. The analysis of these probabilities allows us to propose strategies for donors recruitment in order to increase the phenotypic variability of the registry, then its efficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4fb24113082693d724b6d6d51963fbf9 https://pubmed.ncbi.nlm.nih.gov/10645641 Zobrazit plný text záznamu