Dynamic Image Analysis To Evaluate Subvisible Particles During Continuous Drug Infusion In a Neonatal Intensive Care Unit
| Autor: | Maxime Perez, Bertrand Décaudin, Aurélie Maiguy-Foinard, Christine Barthélémy, Gilles Lebuffe, Laurent Storme, Pascal Odou |
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| Přispěvatelé: | Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), Université de Lille, Droit et Santé, Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Environnement périnatal et croissance - EA 4489 (EPS), Université de Lille, CHU Lille, Institut de Chimie Pharmaceutique Albert Lespagnol [ICPAL], Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA], Environnement périnatal et croissance - EA 4489 [EPS] |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2017, Scientific Reports, 7, ⟨10.1038/s41598-017-10073-y⟩ Scientific Reports, 2017, Scientific Reports, 7, ⟨10.1038/s41598-017-10073-y⟩ Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-10073-y⟩ |
| Popis: | International audience; Studies have shown that infused particles lead to numerous complications such as inflammation or organ dysfunctions in critically ill children. Nevertheless, there is very little data available to evaluate the amount of particulate matter potentially administered to patients, and none with regard to infants. We have investigated the quantity received by these patients during multidrug IV therapies. Two different protocols commonly used in our neonatal intensive care unit (NICU) to manage excessively preterm infants were reproduced in the laboratory and directly connected to a dynamic particle analyser. The particulate matter of infused therapies was measured over 24 h, so that both overall particulate contamination and particle sizes could be determined. No visible particles were observed during drug infusions. Particulate analyses showed a significant number of particles that can reach 85,000 per day, with peaks during discontinuous drug infusions. Moreover, we showed that very large particles of about 60 µm were infused to infants. This study showed that despite very low infusion flow rates, infants may receive a large number of particles during drug infusion, especially in NICUs. Particulate contamination of IV fluids is not without consequences for fragile infants. Preventive solutions could be effective, such as the use of in-line filters. |
| Databáze: | OpenAIRE |
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