Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
| Autor: | Dancer, R.C., Parekh, D., Lax, S., D'Souza, V., Zheng, S., Bassford, C.R., Park, D., Bartis, D.G., Mahida, R., Turner, A.M., Sapey, E., Wei, W., Naidu, B., Stewart, P.M., Fraser, W.D., Christopher, K.B., Cooper, M.S., Gao, F., Sansom, D.M., Martineau, A.R., Perkins, G.D., Thickett, D.R. |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Critical Care Calcitriol Risk Factors Animals Humans Vitamin D Cells Cultured APACHE Aged Calcifediol Respiratory Distress Syndrome Epithelial Cells Middle Aged Vitamin D Deficiency Survival Analysis QP Innate Immunity Esophagectomy Mice Inbred C57BL Pulmonary Alveoli Disease Models Animal Intensive Care Units Gene Expression Regulation ARDS Female RC |
| Zdroj: | Thorax |
| ISSN: | 0040-6376 |
| Popis: | RATIONALE: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated. \ud \ud OBJECTIVES: To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity. \ud \ud METHODS: Human, murine and in vitro primary alveolar epithelial cell work were included in this study. \ud \ud FINDINGS: Vitamin D deficiency (plasma 25(OH)D levels 600 genes. In a clinical setting, pharmacological repletion of vitamin D prior to oesophagectomy reduced the observed changes of in vivo measurements of alveolar capillary damage seen in deficient patients. \ud \ud CONCLUSIONS: Vitamin D deficiency is common in people who develop ARDS. This deficiency of vitamin D appears to contribute to the development of the condition, and approaches to correct vitamin D deficiency in patients at risk of ARDS should be developed. \ud \ud TRIAL REGISTRATION: UKCRN ID 11994. |
| Databáze: | OpenAIRE |
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