Early development of structural networks and the impact of prematurity on brain connectivity

Autor: Batalle, Dafnis, Hughes, Emer J., Zhang, Hui, Tournier, J.-Donald, Tusor, Nora, Aljabar, Paul, Wali, Luqman, Alexander, Daniel C., Hajnal, Joseph V., Nosarti, Chiara, Edwards, A. David, Counsell, Serena J.
Jazyk: angličtina
Rok vydání: 2017
Předmět:
ODI
orientation dispersion index
Male
FDR
false discovery rate
MRI
Magnetic resonance imaging
Cognitive Neuroscience
ROI
region of interest
NODDI
neurite orientation dispersion and density imaging
rODI
relative orientation density index
Gestational Age
CSF
cerebrospinal fluid
Article
Diffusion MRI
PMA
post menstrual age
Image Interpretation
Computer-Assisted
Neural Pathways
Humans
FA
fractional anisotropy
WM
white matter
NDI
neurite density index
NODDI
FS
fraction of streamlines
rNDI
relative neurite density index
DGM
deep grey matter
rFA
relative fractional anisotropy
Infant
Newborn
Brain
GM
grey matter
Newborn
Magnetic Resonance Imaging
ACT
anatomically-constrained tractography
Graph theory
Diffusion Tensor Imaging
Neurology
SIFT
spherical-deconvolution informed filtering of tractograms
Brain mapping
Female
DTI
diffusion tensor imaging
FOD
fibre orientation distribution
CSD
constrained spherical deconvolution
rFS
relative fraction of streamlines
dMRI
diffusion MRI
GA
gestational age
Infant
Premature
SGA
small for gestational age
Zdroj: Neuroimage
Batalle, D, Hughes, E J, Zhang, H, Tournier, J D, Tusor, N, Aljabar, P, Wali, L, Alexander, D C, Hajnal, J V, Nosarti, C, Edwards, A D & Counsell, S J 2017, ' Early development of structural networks and the impact of prematurity on brain connectivity ', NeuroImage, vol. 149, pp. 379-392 . https://doi.org/10.1016/j.neuroimage.2017.01.065
ISSN: 1095-9572
1053-8119
Popis: Preterm infants are at high risk of neurodevelopmental impairment, which may be due to altered development of brain connectivity. We aimed to (i) assess structural brain development from 25 to 45 weeks gestational age (GA) using graph theoretical approaches and (ii) test the hypothesis that preterm birth results in altered white matter network topology. Sixty-five infants underwent MRI between 25+3 and 45+6 weeks GA. Structural networks were constructed using constrained spherical deconvolution tractography and were weighted by measures of white matter microstructure (fractional anisotropy, neurite density and orientation dispersion index). We observed regional differences in brain maturation, with connections to and from deep grey matter showing most rapid developmental changes during this period. Intra-frontal, frontal to cingulate, frontal to caudate and inter-hemispheric connections matured more slowly. We demonstrated a core of key connections that was not affected by GA at birth. However, local connectivity involving thalamus, cerebellum, superior frontal lobe, cingulate gyrus and short range cortico-cortical connections was related to the degree of prematurity and contributed to altered global topology of the structural brain network. The relative preservation of core connections at the expense of local connections may support more effective use of impaired white matter reserve following preterm birth.
Graphical abstract fx1
Highlights • First characterisation of preterm brain networks weighted by microstructural features. • Preterm brain is resistant to disruptions in development of core connections. • Peripheral connections associated with cognition and behaviour are more vulnerable.
Databáze: OpenAIRE
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