[Preliminary results of BFM 96 protocol in treatment of childhood ALL relapse in the experience of the Polish Paediatric Leukaemia /Lymphoma Study Group]
| Autor: | Chybicka, A., Boguslawska-Jaworska, J., Gorczynska, E., Armata, J., Balcerska, A., Balwierz, W., Bubala, H., Filiks-Litwin, B., Kolecki, P., Kowalczyk, J., Lukowska, K., Michał Matysiak, Rokicka-Milewska, R., Rola-Kurc, E., Stencel, D., Sonta-Jakimczyk, D., Strojny, W., Wachowiak, J., Wieczorek, M., Wysocki, M., Zelenay, E. |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Adolescent Daunorubicin Remission Induction Infant Precursor Cell Lymphoblastic Leukemia-Lymphoma Survival Analysis Treatment Outcome Risk Factors Vincristine Child Preschool Antineoplastic Combined Chemotherapy Protocols Asparaginase Humans Prednisone Female Poland Neoplasm Recurrence Local Child Bone Marrow Transplantation Follow-Up Studies |
| Zdroj: | ResearcherID |
| Popis: | Between 1998 and 1999, 36 children aged from 3 months to 18 years (10 girls and 26 boys) with first relapse of acute lymphoblastic leukaemia were included in the study. The children were treated according to the BFM 96 relapse protocol. There were 24 cases with early (including 9 children with very early) and 12 cases with late relapse ( BM-20, local extra BM-6, combined 10). The overall second complete remission (CR) rate was 83,33%. The probability of overall EFS after 2 years was 73,3%. The results obtained with BFM 96 chemotherapy in children with first late relapse are acceptable. For children with early relapses, megachemotherapy with BMT in second remission should be used. |
| Databáze: | OpenAIRE |
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