[Feasability of the dose adjustment of continuous infusion administration over 120 hours of 5-fluorouracil associated with cisplatin]
| Autor: | Bruno Coudert, De Gislain C, Jl, Beltramo, Guigues B, Mayer F, Bruchon Y, Jm, Riedinger, Fargeot P, Dumas M, Guerrin J |
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| Předmět: |
Adult
Male Dose-Response Relationship Drug Bronchial Neoplasms Drug Synergism Middle Aged Drug Administration Schedule Treatment Outcome Head and Neck Neoplasms Area Under Curve Antineoplastic Combined Chemotherapy Protocols Humans Fluorouracil Cisplatin Drug Monitoring Infusions Intravenous Aged Neoplasm Staging |
| Zdroj: | Europe PubMed Central |
| Popis: | Therapeutic monitoring of 120 hours continuous 5-fluorouracil associated with cisplatin. For 31 patients treated by continuous 5-fluorouracil with cisplatin, a therapeutic monitoring of 5-fluorouracil is performed, based on the 48 first hours area under the curve (AUC) and the total AUC. The 5-fluorouracile taylorization allows to reduce some toxicity's while preserving an efficiency (objective responses 42%). Many patients are considered with potentially low 5-fluorouracile clearance. Dose reductions of 5-fluorouracile are frequent, reach 50% during the third cure and allow the achievement of targeted AUC. The role of cisplatin in this necessary reduction of dose is unknown. |
| Databáze: | OpenAIRE |
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