Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects
| Autor: | Gallerani, Eleonora, Proietto, Davide, Dallan, Beatrice, Campagnaro, Marco, Pacifico, Salvatore, Albanese, Valentina, Marzola, Erika, Marconi, Peggy Carla Raffaella, Caputo, Antonella, Victor, Appay, Gavioli, Riccardo, Nicoli, Francesco |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Aging Enzyme-Linked Immunospot Assay viruses Immunology Epitopes T-Lymphocyte cellular immunity CD8-Positive T-Lymphocytes CD8+ T cells Lymphocyte Activation NO Interferon-gamma Young Adult Humans Antigens Viral primary responses Cells Cultured Original Research Aged SARS-CoV-2 COVID-19 RC581-607 epitopes Middle Aged Healthy Volunteers naive T cells Gene Expression Regulation Immunologic diseases. Allergy SARS-CoV-2 immune aging naive T cells cellular immunity epitopes primary responses CD8+ T cells immune aging Peptides |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses. |
| Databáze: | OpenAIRE |
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