[Kappa light chain deposition disease, presenting as Sjögren's syndrome, successfully treated by high-dose melphalan and autologous blood stem transplantation]
| Autor: | C, Foguem, B, Kantelip, E, Deconinck, C, Hafsaoui, N, Méaux-Ruault, H, Gil, N, Magy-Bertrand, J-L, Dupond |
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| Přispěvatelé: | Saas, Philippe, Service d'hématologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service d'Anatomie pathologique [CHRU Besançon], Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC) |
| Jazyk: | francouzština |
| Rok vydání: | 2009 |
| Předmět: |
MESH: Sialography
MESH: Salivary Glands Sialography [SDV.IMM] Life Sciences [q-bio]/Immunology Biopsy Paraproteinemias MESH: Immunoglobulin kappa-Chains Transplantation Autologous Salivary Glands Diagnosis Differential MESH: Electromyography Immunoglobulin kappa-Chains MESH: Biopsy MESH: Melphalan MESH: Paraproteinemias MESH: Diagnosis Differential Humans Melphalan MESH: Humans MESH: Hypertrophy Electromyography Peripheral Nervous System Diseases Hypertrophy MESH: Transplantation Autologous Sjogren's Syndrome MESH: Sjogren's Syndrome [SDV.IMM]Life Sciences [q-bio]/Immunology Female MESH: Peripheral Nervous System Diseases MESH: Stem Cell Transplantation Tomography X-Ray Computed MESH: Tomography X-Ray Computed MESH: Female Stem Cell Transplantation |
| Zdroj: | La Revue de Médecine Interne La Revue de Médecine Interne, Elsevier, 2009, 30 (1), pp.49-52. ⟨10.1016/j.revmed.2008.08.003⟩ La Revue De Médecine Interne La Revue De Médecine Interne, Elsevier, 2009, 30 (1), pp.49-52. ⟨10.1016/j.revmed.2008.08.003⟩ |
| ISSN: | 0248-8663 1768-3122 |
| DOI: | 10.1016/j.revmed.2008.08.003⟩ |
| Popis: | International audience; INTRODUCTION: Light chain deposition disease is a systemic disorder characterised by tissue deposition of monoclonal immunoglobulin light chains without tinctorial properties. It has been exceptionally reported with salivary involvement mimicking Sjögren's syndrome and peripheral neuropathy. CASE REPORT: We report a case of light chain deposition disease associated with plasma cell dyscrasia presenting as sicca syndrome with salivary glands hypertrophy and polyneuropathy successfully treated by high dose melphalan and autologous blood stem transplantation. CONCLUSION: Light chain deposition disease should be recognized as an aetiology of sicca syndrome and peripheral neuropathy. Further studies should assess the prevalence of sicca syndrome in light chain deposition disease and better characterise the neurological manifestations. |
| Databáze: | OpenAIRE |
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