| Autor: |
G, Veronesi, P, Maisonneuve, L, Spaggiari, C, Rampinelli, G, Pelosi, L, Preda, F, Petrella, A, Borri, M, Casiraghi, R, Bertolotti, N, Rotmensz, M, Bellomi |
| Přispěvatelé: |
Veronesi G., Maisonneuve P., Spaggiari L., Rampinelli C., Pelosi G., Preda L., Petrella F., Borri A., Casiraghi M., Bertolotti R., Rotmensz N., Bellomi M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
ecancermedicalscience |
| Popis: |
Background: Low-dose computed tomography (CT) screening can detect early stage lung cancer in high-risk populations. However, no data on repeated annual screening over more than 5 years are available, and the impact of screening on lung cancer mortality is controversial. Methods: We analysed outcomes in high-risk asymptomatic volunteers (smokers and former smokers, >50 years) enrolled in a pilot study over 1 year from June 2000, who received annual low-dose CT for 7 years. Cumulative lung cancer incidence and survival were represented by Kaplan-Meier curves. Standardized incidence and mortality ratios were used to estimate risks relative to the general Italian and US population. Results: Compliance was 86% at the end of the seventh year in 1035 recruited volunteers (71% men, mean age 58 years). Lung cancer was diagnosed in 54 (5.3%); radical surgery was possible in 48/54 (87%); 39/54 (72%) had stage I disease. Five-year survival was 63% overall, 89% for stage I cases. During 6308 person-years of observation, 47 participants had died versus 75 expected in the Italian general population standardised for age and sex. Fourteen lung cancer deaths were registered versus 27 expected in a standardised US smoker population. Conclusions: Seventy percent of screening-diagnosed patients had stage I disease, and the survival of screen-detected cancer patients was high. Lung cancer mortality was favourable compared to age- and sex-matched population of US smokers, suggesting that mortality can be lowered by screening, although larger trials with longer follow-up are necessary to confirm these findings. © the authors; licensee ecancermedicalscience. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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