Botulinum toxin-A treatment reduces human mechanical pain sensitivity and mechanotransduction
| Autor: | Paterson, Kathryn, Lolignier, Stéphane, Wood, John, McMahon, Stephen, Bennett, David |
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| Přispěvatelé: | Wolfson Institute for Biomedical Research (WIBR), University College of London [London] (UCL) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pain Threshold Patch-Clamp Techniques Sensory Receptor Cells CAPSAICIN NOCICEPTORS Brief Communication Mechanotransduction Cellular Membrane Potentials Young Adult Ganglia Spinal EXOCYTOSIS Psychophysics Animals Humans Botulinum Toxins Type A ComputingMilieux_MISCELLANEOUS Cells Cultured Pain Measurement NEUROPATHIC PAIN SECONDARY HYPERALGESIA Healthy Volunteers SENSITIZATION MODEL Mice Inbred C57BL Neuromuscular Agents NEUROTOXIN Hyperalgesia [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology SENSORY NEURONS [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Brief Communications EVOKED PAIN |
| Zdroj: | Annals of Neurology Paterson, K, Lolignier, S, Wood, J N, McMahon, S B & Bennett, D L H 2014, ' Botulinum Toxin-A Treatment Reduces Human Mechanical Pain Sensitivity and Mechanotransduction ', Annals of Neurology, vol. 75, no. 4, pp. 591-596 . https://doi.org/10.1002/ana.24122 Annals of Neurology, Wiley, 2014, 75 (4), pp.591-596. ⟨10.1002/ana⟩ |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.24122 |
| Popis: | The mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A) are not well understood. We have tested the hypothesis that BoNT-A can block nociceptor transduction. Intradermal administration of BoNT-A to healthy volunteers produced a marked and specific decrease in noxious mechanical pain sensitivity, whereas sensitivity to low-threshold mechanical and thermal stimuli was unchanged. BoNT-A did not affect cutaneous innervation. In cultured rodent primary sensory neurons, BoNT-A decreased the proportion of neurons expressing slowly adapting mechanically gated currents linked to mechanical pain transduction. Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent. Ann Neurol 2014;75:591-596 © 2014 The Authors. American Neurological Association. |
| Databáze: | OpenAIRE |
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