| Autor: |
Fouqueau, Thomas, Blombach, Fabian, Cackett, Gwenny, Carty, Alice E., Matelska, Dorota M., Ofer, Sapir, Pilotto, Simona, Phung, Duy Khanh, Werner, Finn |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Emerging Topics in Life Sciences |
| ISSN: |
2397-8554 |
| Popis: |
The archaeal RNA polymerase (RNAP) is a double-psi β-barrel enzyme closely related to eukaryotic RNAPII in terms of subunit composition and architecture, promoter elements and basal transcription factors required for the initiation and elongation phase of transcription. Understanding archaeal transcription is, therefore, key to delineate the universally conserved fundamental mechanisms of transcription as well as the evolution of the archaeo-eukaryotic transcription machineries. The dynamic interplay between RNAP subunits, transcription factors and nucleic acids dictates the activity of RNAP and ultimately gene expression. This review focusses on recent progress in our understanding of (i) the structure, function and molecular mechanisms of known and less characterized factors including Elf1 (Elongation factor 1), NusA (N-utilization substance A), TFS4, RIP and Eta, and (ii) their evolution and phylogenetic distribution across the expanding tree of Archaea. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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