| Autor: |
Marco Alessandro, Minetto, Rizwan, Qaisar, Valentina, Agoni, Giovanna, Motta, Emanuela, Longa, Danilo, Miotti, Maria Antonietta, Pellegrino, Roberto, Bottinelli |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
The aim of this study was to understand the effects of short-term glucocorticoid administration in healthy subjects.Five healthy men received dexamethasone (8 mg/day) for 7 days. Vastus lateralis muscle biopsy and knee extension torque measurement were performed before and after administration. A large number of individual muscle fibers were dissected from the biopsy samples (pre-administration: n = 165, post-administration: n = 177).Maximal knee extension torque increased after administration (∼ 13%), whereas both type 1 and type 2A fibers had decreased cross-sectional area (type 1: ∼ 11%, type 2A: ∼ 17%), myosin loss (type 1: ∼ 18%, type 2A: ∼ 32%), and loss of specific force (type 1: ∼ 24%, type 2A: ∼ 33%), which were preferential for fast fibers.Short-term dexamethasone administration in healthy subjects elicits quantitative and qualitative adaptations of muscle fibers that precede (and may predict) the clinical appearance of myopathy in glucocorticoid-treated subjects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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