| Autor: |
Retailleau, Kevin, Duprat, Fabrice, Arhatte, Malika, Ranade, Sanjeev Sumant, Peyronnet, Rémi, Martins, Joana Raquel, Jodar, Martine, Moro, Céline, Offermanns, Stefan, Feng, Yuanyi, Demolombe, Sophie, Patel, Amanda, Honoré, Eric |
| Jazyk: |
angličtina |
| Předmět: |
|
| Zdroj: |
Cell Reports, Vol 13, Iss 6, Pp 1161-1171 (2015) |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2015.09.072 |
| Popis: |
SummaryThe mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells in the adult remains unknown. Here, we show that Piezo1 is highly expressed in myocytes of small-diameter arteries and that smooth-muscle-specific Piezo1 deletion fully impairs SAC activity. While Piezo1 is dispensable for the arterial myogenic tone, it is involved in the structural remodeling of small arteries. Increased Piezo1 opening has a trophic effect on resistance arteries, influencing both diameter and wall thickness in hypertension. Piezo1 mediates a rise in cytosolic calcium and stimulates activity of transglutaminases, cross-linking enzymes required for the remodeling of small arteries. In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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