A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
| Autor: | Adhikari, Kaustubh, Fuentes-Guajardo, Macarena, Quinto-Sánchez, Mirsha, Mendoza-Revilla, Javier, Camilo Chacón-Duque, Juan, Acuña-Alonzo, Victor, Jaramillo, Claudia, Arias, William, Lozano, Rodrigo Barquera, Pérez, Gastón Macín, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Hunemeier, Tábita, Ramallo, Virginia, Silva de Cerqueira, Caio C., Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Gallo, Carla, Poletti, Giovanni, Schuler-Faccini, Lavinia, Salzano, Francisco M., Bortolini, Maria- Cátira, Canizales-Quinteros, Samuel, Cheeseman, Michael, Rosique, Javier, Bedoya, Gabriel, Rothhammer, Francisco, Headon, Denis, González-José, Rolando, Balding, David, Ruiz-Linares, Andrés |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Population genetics Science purl.org/pe-repo/ocde/ford#1.06.03 [https] Otras Ciencias Biológicas purl.org/pe-repo/ocde/ford#1.03.00 [https] Cadherin Related Proteins morphogenesis Core Binding Factor Alpha 1 Subunit Nerve Tissue Proteins Paired Box Transcription Factors/genetics Polymorphism Single Nucleotide Article purl.org/becyt/ford/1 [https] Core Binding Factor Alpha 1 Subunit/genetics Ciencias Biológicas Mice Young Adult Zinc Finger Protein Gli3 Paired Box Transcription Factors Animals Humans Nerve Tissue Proteins/genetics purl.org/becyt/ford/1.6 [https] Maxillofacial Development Edar Receptor Maxillofacial Development/genetics Anatomic Variation Zinc Finger Protein Gli3/genetics Edar Receptor/genetics stomatognathic diseases Latin America Cadherin Related Proteins/genetics Face genome-wide association studies purl.org/pe-repo/ocde/ford#1.04.00 [https] Face/anatomy & histology CIENCIAS NATURALES Y EXACTAS Genome-Wide Association Study |
| Zdroj: | Adhikari, K, Fuentes-Guajardo, M, Quinto-Sánchez, M, Mendoza-Revilla, J, Camilo Chacón-Duque, J, Acuña-Alonzo, V, Jaramillo, C, Arias, W, Lozano, R B, Pérez, G M, Gómez-Valdés, J, Villamil-Ramírez, H, Hunemeier, T, Ramallo, V, Silva de Cerqueira, C C, Hurtado, M, Villegas, V, Granja, V, Gallo, C, Poletti, G, Schuler-Faccini, L, Salzano, F M, Bortolini, M-C, Canizales-Quinteros, S, Cheeseman, M, Rosique, J, Bedoya, G, Rothhammer, F, Headon, D, González-José, R, Balding, D & Ruiz-Linares, A 2016, ' A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation ', Nature Communications, vol. 7, 11616 . https://doi.org/10.1038/ncomms11616 Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016) Nature Communications CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms11616 |
| Popis: | We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|