Soil-transmitted helminth infection in pregnancy and long-term child neurocognitive and behavioral development: A prospective mother-child cohort in Benin

Autor: Garrison, Amanda, Boivin, Michael, Khoshnood, Babak, Courtin, David, Alao, Jules, Mireku, Michael, Ibikounle, Moudachirou, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence
Přispěvatelé: Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Michigan State University [East Lansing], Michigan State University System, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), University of Lincoln, Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Fondation de France (2015 00060746), Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD- R21-HD060524), European and Developing Countries Clinical Trials Partnership (EDCTP- IP.07.31080.002), Bill and Melinda Gates Foundation, EHESP, SCD, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), Université d’Abomey-Calavi (UAC)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Maternal Health
Emotions
RC955-962
Helminthiasis
Child Behavior
Social Sciences
Cohort Studies
C890 Psychology not elsewhere classified
Soil
Families
C810 Applied Psychology
Child Development
Cognition
Medical Conditions
Pregnancy
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Psychology
Prospective Studies
C820 Developmental Psychology
Child
Children
Immune Response
Cognitive Neurology
Neuropsychological testing
Eukaryota
Obstetrics and Gynecology
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Cognitive impairment
Neurology
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Female
Public aspects of medicine
RA1-1270
B990 Subjects Allied to Medicine not elsewhere classified
Research Article
Adult
Helminth infections
Cognitive Neuroscience
Immunology
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Signs and Symptoms
[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics
Helminths
Parasitic Diseases
Humans
Animals
Inflammation
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
Organisms
Biology and Life Sciences
Invertebrates
[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Age Groups
Hookworms
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Pregnancy Complications
Parasitic
People and Places
Women's Health
Cognitive Science
Population Groupings
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Clinical Medicine
Zoology
[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Neuroscience
Zdroj: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009260 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2021, 15 (3), ⟨10.1371/journal.pntd.0009260⟩
PLoS Neglected Tropical Diseases, Public Library of Science, 2021, 15 (3), ⟨10.1371/journal.pntd.0009260⟩
ISSN: 1935-2735
1935-2727
Popis: Background An estimated 30% of women in Sub-Saharan Africa suffer from soil-transmitted helminth infection during pregnancy (SHIP), which has been shown to increase risk of pre-term birth, low birth weight, and maternal anemia. A previous study in Benin found that SHIP was associated with impaired cognitive and gross motor development scores in 635 one-year-old children. The objective of the present study was to follow children prospectively to investigate whether the association between SHIP and child neurocognitive and behavioral development persisted at age six. Principal findings Our prospective child cohort included 487 live-born singletons of pregnant women enrolled in the Malaria in Pregnancy Preventive Alternative Drugs clinical trial in Allada, Benin. SHIP was assessed at three antenatal visits (ANVs) through collection and testing of stool samples. Neurocognitive and behavioral development was assessed in six-year-old children by trained investigators using the Kaufman Assessment Battery for Children 2nd edition and the parent-reported Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models generated coefficients and 95% confidence intervals and potential mediating factors were tested. Prevalence of SHIP was 13% at the 1st ANV, 9% at the 2nd ANV, and 1% at delivery. SHIP was not associated with low neurocognitive scores in children at six years. Higher SDQ internalizing scores, indicating increased emotional impairments in children, were associated with helminth infection at the 2nd ANV/delivery 1.07 (95% CI 0.15, 2.00) and at least once during pregnancy 0.79 (95% CI 0.12, 1.46) in adjusted models. Mediation analysis did not reveal significant indirect effects of several mediators on this association. Conclusions Our study shows that while SHIP is not associated with impaired long-term neurocognitive development, infections may have significant negative impacts on emotional development in six-year-old children. SHIP remains a critical public health issue, and adequate prevention and treatment protocols should be enforced in low- and middle-income countries.
Author summary Soil-transmitted helminth infections impact 1.5 billion individuals, primarily in low- and middle- income countries, each year and contribute to malnutrition, anemia, and impaired neurocognitive development in children. However, these infections in pregnancy and their impact on offspring have been less studied. One previous study found associations between soil-transmitted helminth infection during pregnancy and impaired cognitive functioning in offspring one year after birth. The current study aimed to follow these children prospectively until six years in order to confirm whether these associations persisted or not. Infections during pregnancy were no longer associated with cognitive or motor functioning in children; however, infections were associated with impaired behavioral development. Animal-based models have hypothesized maternal inflammation and poor birth outcomes to be the mechanisms behind this relationship; however, our findings did not support these mechanisms. This is one of very few prospective cohort studies in Sub-Saharan Africa to investigate these associations, and more research is needed to corroborate results. Limitations include limited power and the possibility that results are due to chance from multiple statistical tests. Adequate and accessible prevention and treatment efforts in pregnancy and childhood should be provided to populations in low- and middle- income countries at high risk of infection.
Databáze: OpenAIRE
Externí odkaz: