Efficacy of conventional-dose cytarabine, idarubicin and thioguanine versus intermediate-dose cytarabine and idarubicin in the induction treatment of acute myeloid leukemia: Long-term results of the prospective randomized nationwide AML-2003 study by the Finnish Leukemia Group

Autor:	Kolonen, Aarne, Sinisalo, Marjatta, Huhtala, Heini, Rimpiläinen, Johanna, Rintala, Hannele, Sankelo, Marja, Koivunen, Elli, Silvennoinen, Raija, Räty, Riikka, Ruutu, Tapani, Volin, Liisa, Porkka, Kimmo, Jantunen, Esa, Nousiainen, Tapio, Kuittinen, Taru, Penttilä, Karri, Pyörälä, Marja, Säily, Marjaana, Koistinen, Pirjo, Kauppila, Marjut, Itälä-Remes, Maija, Ollikainen, Hanna, Rauhala, Auvo, Kairisto, Veli, Pelliniemi, Tarja Terttu, Elonen, Erkki
Přispěvatelé:	Tampere University, Department of Internal medicine, Clinical Medicine, Health Sciences, Department of Clinical Chemistry
Rok vydání:	2022
Předmět:	Leukemia Myeloid Acute Neoplasm Residual Antineoplastic Combined Chemotherapy Protocols Remission Induction Cytarabine Humans Prospective Studies Middle Aged 3121 Internal medicine Idarubicin Thioguanine Finland
Zdroj:	European journal of haematologyREFERENCES. 109(3)
ISSN:	1600-0609
Popis:	Objectives: AML-2003 study sought to compare the long-term efficacy and safety of IAT and IdAraC-Ida in induction chemotherapy of acute myeloid leukemia (AML) and introduce the results of an integrated genetic and clinical risk classification guided treatment strategy. Methods: Patients were randomized to receive either IAT or IdAraC-Ida as the first induction treatment. Intensified postremission strategies were employed based on measurable residual disease (MRD) and risk classification. Structured questionnaire forms were used to gather data prospectively. Results: A total of 356 AML patients with a median age of 53 years participated in the study. Long-term overall survival (OS) and relapse-free survival (RFS) were both 49% at 10 years. The median follow-up was 114 months. No significant difference in remission rate, OS or RFS was observed between the two induction treatments. Risk classification according to the protocol, MRD after the first and the last consolidation treatment affected the OS and RFS significantly (p
Databáze:	OpenAIRE
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