Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation
| Autor: | Mostapha Ariane, Mohamed Hatem Allouche, Marco Bussone, Fausto Giacosa, Frédéric Bernard, Mostafa Barigou, Alessio Alexiadis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
States of Matter
Physiology lcsh:Medicine Fluid Mechanics Research and Analysis Methods Continuum Mechanics Biochemistry Membrane Potential Calcification Medicine and Health Sciences Biochemical Simulations lcsh:Science Fluid Flow Damage Mechanics Fluids Physics Simulation and Modeling lcsh:R Models Cardiovascular Classical Mechanics Biology and Life Sciences Computational Biology Fluid Dynamics Liquids Deformation Blood Vessel Prosthesis Electrophysiology Blood Circulation Physical Sciences Hydrodynamics lcsh:Q Physiological Processes Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 4, p e0174795 (2017) |
| ISSN: | 1932-6203 |
| Popis: | We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|