[Gel-forming mucins structure governs mucus gels viscoelasticity]

Autor: Demouveaux, Bastien, Gouyer, Valérie, Magnien, Mylene, Plet, Ségolène, Gottrand, Frederic, Narita, Tetsuharu, Desseyn, Jean-Luc
Přispěvatelé: Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Inserm, Université de Lille, CHU Lille, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, Lille Inflammation Research International Center - U 995 [LIRIC], Lille Inflammation Research International Center (LIRIC) - U995, Université de Lille, LillOA
Jazyk: francouzština
Rok vydání: 2018
Předmět:
Zdroj: Medecine sciences
Medecine sciences, 2018, Medecine sciences, 34, pp.806-812. ⟨10.1051/medsci/2018206⟩
ISSN: 1958-5381
DOI: 10.1051/medsci/2018206⟩
Popis: International audience; Mucus is the first line of innate mucosal defense in all mammals. Gelforming mucins control the rheological properties of mucus hydrogels by forming a network in which hydrophilic and hydrophobic regions coexist, and it has been revealed that the network is formed through both covalent links and reversible links such as hydrophobic interactions in order to modulate the structure as a function of the physiological necessities. Here, we review the structure and functions of the mucus in terms of the gel-forming mucins protein-protein interactions, also called interactome. Since it is difficult to characterize the low energy reversible interactions due to their dependence on physico-chemical environment, their role is not well understood. Still, they constitute a promising target to counteract mucus abnormalities observed in mucus-associated diseases.
Databáze: OpenAIRE
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