How Protein Methylation Regulates Steroid Receptor Function
| Autor: | Malbeteau, Lucie, Pham, Ha Thuy, Eve, Louisane, Stallcup, Michael, Poulard, Coralie, Le Romancer, Muriel |
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| Přispěvatelé: | Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Southern California (USC), Manship, Brigitte |
| Rok vydání: | 2021 |
| Předmět: |
Receptors
Steroid steroid receptors [SDV.CAN]Life Sciences [q-bio]/Cancer coregulators Review protein demethylases Methylation PR GR [SDV.CAN] Life Sciences [q-bio]/Cancer protein arginine methyltransferases Humans Protein Methyltransferases lysine methyltransferases Protein Processing Post-Translational AcademicSubjects/MED00250 ERα AR |
| Zdroj: | Endocrine Reviews Endocrine reviews Endocrine reviews, 2022, 43 (1), pp.160-197. ⟨10.1210/endrev/bnab014⟩ |
| ISSN: | 1945-7189 0163-769X |
| DOI: | 10.1210/endrev/bnab014⟩ |
| Popis: | Steroid receptors (SRs) are members of the nuclear hormonal receptor family, many of which are transcription factors regulated by ligand binding. SRs regulate various human physiological functions essential for maintenance of vital biological pathways, including development, reproduction, and metabolic homeostasis. In addition, aberrant expression of SRs or dysregulation of their signaling has been observed in a wide variety of pathologies. SR activity is tightly and finely controlled by post-translational modifications (PTMs) targeting the receptors and/or their coregulators. Whereas major attention has been focused on phosphorylation, growing evidence shows that methylation is also an important regulator of SRs. Interestingly, the protein methyltransferases depositing methyl marks are involved in many functions, from development to adult life. They have also been associated with pathologies such as inflammation, as well as cardiovascular and neuronal disorders, and cancer. This article provides an overview of SR methylation/demethylation events, along with their functional effects and biological consequences. An in-depth understanding of the landscape of these methylation events could provide new information on SR regulation in physiology, as well as promising perspectives for the development of new therapeutic strategies, illustrated by the specific inhibitors of protein methyltransferases that are currently available. Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
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